Rapid regulation of tonic GABA currents in cultured rat hippocampal 1 neurons
نویسندگان
چکیده
By 3 4 Christopher B. Ransom, Wucheng Tao , Yuanming Wu, William J. Spain, 5 and George B. Richerson 6 7 Epilepsy Center of Excellence, VA Puget Sound HealthCare System; Dept of 8 Neurology and Dept of Physiology and Biophysics, University of Washington, 9 Seattle, WA; Dept of Neurology and Dept. of Molecular Physiology and 10 Biophysics, University of Iowa, Iowa City, IA 11 12
منابع مشابه
Rapid regulation of tonic GABA currents in cultured rat hippocampal neurons.
Subacute and chronic changes in tonic GABAergic inhibition occur in human and experimental epilepsy. Less is known about how tonic inhibition is modulated over shorter time frames (seconds). We measured endogenous tonic GABA currents from cultured rat hippocampal neurons to evaluate how they are affected by 1) transient increases in extracellular GABA concentration ([GABA]), 2) transient postsy...
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gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter, activates a persistent low amplitude tonic current in several brain regions in addition to conventional synaptic currents. Here we demonstrate that GABA(A) receptors mediating the tonic current in hippocampal neurons exhibit functional and pharmacological properties different from those of quantal synaptic currents. Patc...
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Ambient GABA in the brain activates GABA(A) receptors to produce tonic inhibition. Membrane potential influences both GABA transport and GABA(A) receptors and could thereby regulate tonic inhibition. We investigated the voltage dependence of tonic currents in cultured rat hippocampal neurons using patch-clamp techniques. Tonic GABA(A) conductance increased with depolarization from 15 +/- 3 pS/p...
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تاریخ انتشار 2012